α,β-不饱和砜的催化对映选择性共轭加成反应
Catalytic enantioselective conjugate additions with α,β-unsaturated sulfones.
作者信息
Li Hongming, Song Jun, Deng Li
机构信息
Department of Chemistry, Brandeis University, Waltham, Massachuesttes, 02454-9110, USA.
出版信息
Tetrahedron. 2009 Apr 18;65(16):3139-3148. doi: 10.1016/j.tet.2008.11.054.
Abstract
We describe the development of a highly efficient catalytic asymmetric conjugate addition to α,β-unsaturated sulfones. Utilizing practical bifunctional organic catalysts and involving air- and moisture-tolerant conditions, conjugate additions of a wide range of Michael donors to α,β-unsaturated sulfones proceeded in excellent enantioselectivity/diastereoselectivity and high yield. This efficient and operationally simple new catalytic asymmetric reaction should provide a versatile approach for the asymmetric synthesis of chiral sulfones bearing all-carbon quaternary stereocenters.
摘要
我们描述了一种用于α,β-不饱和砜的高效催化不对称共轭加成反应的发展。利用实用的双功能有机催化剂并在耐空气和耐湿气条件下，多种迈克尔给体与α,β-不饱和砜的共轭加成反应以优异的对映选择性/非对映选择性和高收率进行。这种高效且操作简单的新型催化不对称反应应为合成带有全碳季碳立体中心的手性砜提供一种通用方法。
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