Cheney C Parks, Srijanto B, Hedden D L, Gehl A, Ferrell T L, Schultz J, Engleman E A, McBride W J, O'Connor S
University of Tennessee, Department of Physics and Astronomy, Knoxville, TN 37996-1200, United States.
Sens Actuators B Chem. 2009 Apr 24;138(1):264-269. doi: 10.1016/j.snb.2009.01.052.
Traditional alcohol studies measure blood alcohol concentration to elucidate the biomedical factors that contribute to alcohol abuse and alcoholism. These measurements require large and expensive equipment, are labor intensive, and are disruptive to the subject. To alleviate these problems, we have developed an implantable, wireless biosensor that is capable of measuring alcohol levels for up to six weeks. Ethanol levels were measured in vivo in the interstitial fluid of a Wistar rat after administering 1 g/kg and 2 g/kg ethanol by intraperitoneal (IP) injection. The data were transmitted wirelessly using a biosensor selective for alcohol detection. A low-power piezoresistive microcantilever sensor array was used with a polymer coating suitable for measuring ethanol concentrations at 100% humidity over several hours. A hydrophobic, vapor permeable nanopore membrane was used to screen liquid and ions while allowing vapor to pass to the sensor from the subcutaneous interstitial fluid.
传统的酒精研究通过测量血液酒精浓度来阐明导致酒精滥用和酗酒的生物医学因素。这些测量需要大型且昂贵的设备， labor intensive，并且对受试者有干扰。为了缓解这些问题，我们开发了一种可植入的无线生物传感器，它能够测量长达六周的酒精水平。通过腹腔注射给予1 g/kg和2 g/kg乙醇后，在Wistar大鼠的间质液中对乙醇水平进行了体内测量。数据使用对酒精检测具有选择性的生物传感器进行无线传输。使用了一种低功率压阻微悬臂梁传感器阵列，并配有适合在100%湿度下数小时测量乙醇浓度的聚合物涂层。使用疏水、透气的纳米孔膜来筛选液体和离子，同时允许蒸汽从皮下间质液传递到传感器。 （注：“labor intensive”可能表述有误，暂按原文翻译）
