氨基-1,4-二氢苯并[d][1,2]二硫醚衍生物的合成及氧化还原酶调节作用
Synthesis and redox-enzyme modulation by amino-1,4-dihydro-benzo[d][1,2]dithiine derivatives.
作者信息
Espinosa Sandraliz, Solivan Melissa, Vlaar Cornelis P
机构信息
School of Pharmacy, Medical Sciences Campus, University of Puerto Rico, PO Box 365067, San Juan, PR00936, Puerto Rico.
出版信息
Tetrahedron Lett. 2009 Jun 24;50(25):3023-3026. doi: 10.1016/j.tetlet.2009.03.209.
Abstract
A convenient method to prepare a series of benzodithiine derivatives was developed, via the synthesis of cyclic disulfide building blocks containing an amino-group linker. Some of the novel cyclic disulfide compounds are shown to modulate the activity of the redox-enzyme glutathione reductase.
摘要
通过合成含有氨基连接基的环状二硫键构建块，开发了一种制备一系列苯并二硫醚衍生物的简便方法。一些新型环状二硫键化合物显示出可调节氧化还原酶谷胱甘肽还原酶的活性。
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