Synthesis of an enantiopure isoxazolidine monomer for β-aspartic acid in chemoselective β-oligopeptide synthesis.
作者信息
Ishida Hiroshi, Carrillo Nancy, Bode Jeffrey W
机构信息
Roy and Diana Vagelos Laboratories, Department of Chemistry, Univeristy of Pennsylvania, Philadelphia, PA 19104.
出版信息
Tetrahedron Lett. 2009 Jul 1;50(26):3258-3260. doi: 10.1016/j.tetlet.2009.02.045.
Abstract
The synthesis of an enantiopure isoxazolidine monomer for the incorporation of β(3)-apartic acid residues into β(3)-oligopeptides via chemoselective α-ketoacid-hydroxylamine amide formation. This route involves nitrone cycloaddition of 3-thiophenylpropanal and circumvents limitations of other potential starting materials.
摘要
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