牛羧肽酶：18 号染色体上两个 CES1 和五个 CES 基因家族的证据。
Bovine Carboxylesterases: Evidence for Two CES1 and Five Families of CES Genes on Chromosome 18.
机构信息
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA.
出版信息
Comp Biochem Physiol Part D Genomics Proteomics. 2009 Mar 1;4(1):11-20. doi: 10.1016/j.cbd.2008.09.002.
Predicted bovine carboxylesterase (CES) protein and gene sequences were derived from bovine (Bos taurus) genomic sequence data. Two bovine CES1 genes (CES1.1 and CES1.2) were located on chromosome 18 encoding amino acid sequences that were 81% identical. Two forms of CES1.2 were also observed apparently caused by an indel polymorphism encoded at the C-terminus end. Two CES gene clusters were observed on chromosome 18: CES5-CES1.1-CES1.2 and CES2-CES3-CES6. Bovine CES1, CES2, CES3, CES5 and CES6 shared 39-45% identity with each other, but showed 71-76% identity with each of the five corresponding human CES family members. Phylogeny studies indicated that bovine CES genes originated from five ancestral gene duplication events which predated the eutherian mammalian common ancestor. In addition, a subsequent CES1 gene duplication event is proposed during mammalian evolution prior to the appearance of the Bovidae common ancestor ~ 20 MY ago.
预测的牛羧酸酯酶（CES）蛋白和基因序列源自牛（Bos taurus）基因组序列数据。两个牛 CES1 基因（CES1.1 和 CES1.2）位于 18 号染色体上，编码的氨基酸序列有 81%的同源性。还观察到 CES1.2 的两种形式，显然是由 C 末端的插入/缺失多态性引起的。在 18 号染色体上观察到两个 CES 基因簇：CES5-CES1.1-CES1.2 和 CES2-CES3-CES6。牛 CES1、CES2、CES3、CES5 和 CES6 彼此之间的同源性为 39-45%，但与五个人类 CES 家族成员中的每一个的同源性为 71-76%。系统发育研究表明，牛 CES 基因起源于五个祖先基因复制事件，这些事件发生在真兽类哺乳动物的共同祖先之前。此外，在大约 2000 万年前牛科动物的共同祖先出现之前，哺乳动物进化过程中还发生了一次 CES1 基因复制事件。
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