通过氧化钯（II）催化的Heck型偶联从炔烃快速构建烯炔
Expeditious Enyne Construction from Alkynes via Oxidative Pd(II) Catalyzed Heck-Type Coupling.
作者信息
Hadi Victor, Yoo Kyung Soo, Jeong Min, Jung Kyung Woon
机构信息
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, CA 90089-1661.
出版信息
Tetrahedron Lett. 2009 May 20;50(20):2370-2373. doi: 10.1016/j.tetlet.2009.02.217.
Abstract
The enyne, ubiquitous in natural products, can be a challenge to generate since these moieties require many synthetic transformations to assemble them. We developed a simpler protocol to construct enynes while we found that this oxidative reaction was tolerant in substrate scope. In addition, the utility of this reaction was demonstrated through the attempt in synthesizing antifungal agent Lamisi.
摘要
烯炔结构在天然产物中普遍存在，但由于这些部分需要许多合成转化来组装，因此生成它们可能具有挑战性。我们开发了一种更简单的方案来构建烯炔，同时我们发现这种氧化反应在底物范围上具有耐受性。此外，通过尝试合成抗真菌剂拉米西，证明了该反应的实用性。
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