Ghosh Sanjay
Urticaria Clinic, Institute of Allergic and Immunological Skin Diseases, Kolkata, India.
Indian J Dermatol. 2009 Jul;54(3):280-2. doi: 10.4103/0019-5154.55642.
Urticaria, a perplexing disease of ever-changing explanations, is being renovated almost everyday by newer facts and findings accumulated from different parts of the globe. Cost of the urticaria treatment gradually grows higher and higher whereas the ailment disturbs the quality of life very adversely. Disorder of coagulation cascade has recently thrown some new light into its mechanism. Non-allergic angioedema induced by bradykinin caused by genetic defects and ACE-inhibitors has also been noted. Role of H. pylori in the pathogenesis of urticaria has also been re-reviewed. Urticaria could sometimes mimic erythema multiforme and is termed urticaria multiforme. Skin biopsy showed features of vasculitis in good number of urticaria irrespective of clinical features. Contact sensitization showed positive results in certain cases thus proving contact urticaria. Topical clobetasol, systemic omalizumab and NB UVB have shown promising results in certain forms of urticaria.
荨麻疹，一种解释不断变化且令人困惑的疾病，几乎每天都因全球各地积累的新事实和新发现而被重新认识。荨麻疹的治疗成本逐渐越来越高，而这种疾病对生活质量产生了非常不利的影响。凝血级联紊乱最近为其发病机制带来了一些新线索。由遗传缺陷和血管紧张素转换酶抑制剂引起的缓激肽诱导的非过敏性血管性水肿也已被注意到。幽门螺杆菌在荨麻疹发病机制中的作用也得到了重新审视。荨麻疹有时可模仿多形红斑，被称为多形性荨麻疹。皮肤活检显示，无论临床特征如何，相当数量的荨麻疹都有血管炎的特征。在某些病例中，接触致敏试验呈阳性，从而证实了接触性荨麻疹。外用氯倍他索、全身性奥马珠单抗和窄谱中波紫外线在某些类型的荨麻疹中已显示出有希望的结果。
