Souza A, Aka K J
Laboratoire de Physiologie Animale, Electrophysiologie et de Pharmacologie, Faculté des Sciences, Université des Sciences et Techniques de Masuku, Franceville, Gabon.
Afr J Tradit Complement Altern Med. 2007 Feb 16;4(3):261-6.
The effect of aqueous extract of Tamarindus indica (AETI) was studied on the guinea pig taenia coli, due to its use for treatment of constipation in traditional medicines. AETI, at concentrations ranging from 10(-8) mg/ml to 10(-2) mg/ml, increased the spontaneous contractile activity of guinea pig taenia coli in a dose-dependent manner (EC50 = 4x10(-6) mg/ml). This activity was unaffected by atropine. In high K(+), Ca(2+)-free solution containing EDTA, AETI as well as acetylcholine, used as a control, induced tonic contraction. These results suggest that the plant extract exert a spasmogenic effect that would not involve cholinergic mechanism of action. However, these active principles could mobilize both extra cellular calcium and intracellular calcium from internal stores.
由于罗望子在传统医学中用于治疗便秘，因此研究了罗望子水提取物（AETI）对豚鼠结肠带的作用。浓度范围为10（-8）mg/ml至10（-2）mg/ml的AETI以剂量依赖性方式增加豚鼠结肠带的自发收缩活性（EC50 = 4x10（-6）mg/ml）。这种活性不受阿托品的影响。在含有EDTA的高钾、无钙溶液中，AETI以及用作对照的乙酰胆碱诱导强直性收缩。这些结果表明，该植物提取物发挥了一种不涉及胆碱能作用机制的致痉作用。然而，这些活性成分可以从细胞外和细胞内储存中动员钙。
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