罗望子果实的解痉活性
Spasmolytic Activity of Fruits of Tamarindus indica L.
作者信息
Ali N, Shah Swa
机构信息
Department of Pharmacy, University of Malakand, Chakdara, Dir (Lower). Khyber Pakhtunkhwa, Pakistan.
出版信息
J Young Pharm. 2010 Jul;2(3):261-4. doi: 10.4103/0975-1483.66805.
OBJECTIVE
To study the possible effects of methanolic extract of fruits of Tamarindus indica on rabbit's jejunum preparations.
MATERIALS AND METHODS
The study was carried out on rabbit's jejunum preparations. Methanolic extract of fruits of T. indica was applied in different doses. Potassium chloride (KCl 80 mM)-induced contractions were relaxed by the extract. For determination of possible mode of action of relaxing effects, calcium chloride curves were constructed in decalcified tissues using K(+) normal and followed by K(+) rich solution. The curves were then compared with verapamil.
RESULTS
Relaxant effects on KCl-induced contractions were prominent at a concentration of 5.0-10.0 mg/ml (P<0.05). A right shift at a concentration of 3.0 mg/ml (EC(50) ± SEM = 1.98 ± 0.03) and 10.0 mg/ml (EC(50) ± SEM = 1.79 ± 0.05) versus control (EC(50) ± SEM = 2.33 ± 0.058) resembled the effects of verapamil on the calcium chloride curves.
CONCLUSION
The results confirmed its possible mode of relaxing effects i.e. through calcium channel blockade.
目的
研究罗望子果实甲醇提取物对兔空肠标本的可能作用。
材料与方法
本研究在兔空肠标本上进行。应用不同剂量的罗望子果实甲醇提取物。提取物可舒张氯化钾（80 mM KCl）诱导的收缩。为确定舒张作用的可能作用方式，在脱钙组织中使用正常钾溶液和富钾溶液构建氯化钙曲线，然后将这些曲线与维拉帕米的曲线进行比较。
结果
在浓度为5.0 - 10.0 mg/ml时，对氯化钾诱导的收缩的舒张作用显著（P<0.05）。与对照组（EC(50) ± SEM = 2.33 ± 0.058）相比，在浓度为3.0 mg/ml（EC(50) ± SEM = 1.98 ± 0.03）和10.0 mg/ml（EC(50) ± SEM = 1.79 ± 0.05）时的右移类似于维拉帕米对氯化钙曲线的作用。
结论
结果证实了其可能的舒张作用方式，即通过钙通道阻滞。
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