马哈利樱桃核的脂质成分及抗过敏活性评价
Lipid fraction constituents and evaluation of anti-anaphylactic activity of Prunus mahaleb L. kernels.
作者信息
Shams Khaled A, Schmidt Richard
机构信息
Phytochemistry Dept., National Research Centre, Cairo, Egypt.
出版信息
Afr J Tradit Complement Altern Med. 2007 Feb 16;4(3):289-93. doi: 10.4314/ajtcam.v4i3.31221.
The lipid fraction constituents as well as evaluation of anti-anaphylactic activity of Prunus mahaleb L. kernels were studied. Prunus mahaleb L. kernels were obtained from the local market in Cairo, Egypt. Investigation of the fatty acids revealed that oleic and linoleic acids are the major constituents. 12 compounds were identified from the hydrocarbon fraction. The sterol fraction comprises of cholesterol, stigmasterol, beta-sitosterol and campesterol. The pharmacotoxicity studies were carried out on total and defatted ethanolic extracts as well as the oil fraction. The oil fraction proved to be extremely safe and free from any acute lethal toxicity in intraperitoneal (i.p.) and oral doses up to 100 ml/kg. In vivo assessment of prophylactic efficacy was afforded by 7 days course of daily medication schedule of sensitized adult male guinea pigs against ovalbumin bronchospasm. The prophylactic anti-inflammatory activity of the total ethanolic extract was higher than that of the defatted ethanolic extract. In addition, the lipid fraction of Prunus mahaleb L. kernels evoked complete anti-inflammatory efficacy among the survival animals receiving low and medium doses.
对马哈利李（Prunus mahaleb L.）果仁的脂质成分及其抗过敏活性进行了研究。马哈利李果仁购自埃及开罗当地市场。对脂肪酸的研究表明，油酸和亚油酸是主要成分。从烃类组分中鉴定出12种化合物。甾醇组分包括胆固醇、豆甾醇、β-谷甾醇和菜油甾醇。对总乙醇提取物、脱脂乙醇提取物以及油相部分进行了药物毒性研究。油相部分经腹腔注射（i.p.）和口服给药，剂量高达100 ml/kg时，被证明极其安全且无任何急性致死毒性。通过对致敏成年雄性豚鼠进行为期7天的每日给药方案，对卵清蛋白支气管痉挛进行体内预防性疗效评估。总乙醇提取物的预防性抗炎活性高于脱脂乙醇提取物。此外，马哈利李果仁的脂质部分在接受低剂量和中等剂量的存活动物中诱发了完全的抗炎效果。
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