Adediwura Fred-Jaiyesimi, Kio Abo
Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
Afr J Tradit Complement Altern Med. 2008 Jan 22;5(2):154-7. doi: 10.4314/ajtcam.v5i2.31267.
The methanol extract of Gladiolus psittascinus bulb was evaluated for its antidiabetic activities in alloxan-induced diabetic rats. Blood glucose levels of the glucose loaded and alloxan-induced diabetic rats were estimated over 180 minutes using the O-toluidine and glucose-oxidase methods. The methanol extract at 1 g/kg dose exhibited 16.2% decrease in blood glucose level in the glucose loaded rats and a peak effect of 78.9% in the alloxan-induced diabetic rats. The extract exhibited significant blood glucose lowering effects in the oral glucose tolerance test and type 2 diabetic rats. This study shows a possible beneficial effect of Gladiolus psittascinus in the management of non-insulin dependent diabetes (NIDDM).
对鹦鹉兰球茎的甲醇提取物在四氧嘧啶诱导的糖尿病大鼠中进行抗糖尿病活性评估。使用邻甲苯胺法和葡萄糖氧化酶法在180分钟内测定葡萄糖负荷和四氧嘧啶诱导的糖尿病大鼠的血糖水平。1 g/kg剂量的甲醇提取物使葡萄糖负荷大鼠的血糖水平降低了16.2%，在四氧嘧啶诱导的糖尿病大鼠中峰值效应为78.9%。该提取物在口服葡萄糖耐量试验和2型糖尿病大鼠中表现出显著的降血糖作用。本研究表明鹦鹉兰在非胰岛素依赖型糖尿病（NIDDM）的管理中可能具有有益作用。
