Department of Biology, Washington University, St. Louis, MO 63130-4899, USA.
Int J Mol Sci. 2010 Jan 8;11(1):124-39. doi: 10.3390/ijms11010124.
The genetic variation found in small regions of the genomes of many species can be arranged into haplotype trees that reflect the evolutionary genealogy of the DNA lineages found in that region and the accumulation of mutations on those lineages. This review demonstrates some of the many ways in which clades (branches) of haplotype trees have been applied in recent years, including the study of genotype/phenotype associations at candidate loci and in genome-wide association studies, the phylogeographic history of species, human evolution, the conservation of endangered species, and the identification of species.
在许多物种基因组的小区域中发现的遗传变异，可以排列成单倍型树，反映出该区域中 DNA 谱系的进化史，以及这些谱系上突变的积累。本综述展示了近年来单倍型树分支(clade)在多个方面的应用，包括候选基因座和全基因组关联研究中基因型/表型的关联、物种的系统地理学历史、人类进化、濒危物种的保护以及物种的鉴定。
