离子液体辅助传递难溶性药物。
Ionic liquid-assisted transdermal delivery of sparingly soluble drugs.
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka, Fukuoka 819-0395, Japan.
出版信息
Chem Commun (Camb). 2010 Mar 7;46(9):1452-4. doi: 10.1039/b907462g. Epub 2010 Jan 14.
DOI:10.1039/b907462g
PMID:20162145
Abstract
We report the first successful application of a novel IL-assisted non-aqueous microemulsion stabilized by a blend of two nontoxic surfactants, polyoxyethylene sorbitan monooleate (Tween-80), and sorbitan laurate (Span-20) for transdermal delivery of acyclovir, which is insoluble or sparingly soluble in water and most common organic liquids.
摘要
我们报告了首例新型白细胞介素辅助的非水微乳液的成功应用，该微乳液由两种无毒表面活性剂聚氧乙烯山梨醇单油酸酯（Tween-80）和山梨坦月桂酸酯（Span-20）的混合物稳定，用于阿昔洛韦的经皮递送，阿昔洛韦在水中和大多数常见有机溶剂中不溶或几乎不溶。
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