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离子液体在生物医学中的最新进展。

Recent Advances in Ionic Liquids in Biomedicine.

机构信息

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.

Wyss Institute of Biologically Inspired Engineering, Boston, MA, 02115, USA.

出版信息

Adv Sci (Weinh). 2021 Sep;8(17):e2004819. doi: 10.1002/advs.202004819. Epub 2021 Jul 10.

DOI:10.1002/advs.202004819
PMID:34245140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8425867/
Abstract

The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics and discuss their biomedical applications, namely solubilization of drugs, creation of active pharmaceutical ingredients, delivery of pharmaceuticals through biological barriers, stabilization of proteins and other nucleic acids, antibacterial agents, and development of new biosensors. Current challenges and future outlooks are discussed, including biocompatibility, the potential impact of the presence of impurities, and the importance of understanding the microscopic interactions in ionic liquids in order to design task-specific solvents.

摘要

近年来，由于离子液体和深共晶溶剂具有独特的性质和内在的可调变性，它们在生物医学应用中的使用有了显著的增长。这篇综述将介绍离子液体和深共晶溶剂，并讨论它们在生物医学中的应用，即药物的增溶、活性药物成分的制备、药物透过生物屏障的传递、蛋白质和其他核酸的稳定、抗菌剂以及新型生物传感器的开发。讨论了当前的挑战和未来的展望，包括生物相容性、杂质存在的潜在影响，以及理解离子液体中微观相互作用以设计特定任务溶剂的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/4e5685a503b1/ADVS-8-2004819-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/3ec237402b18/ADVS-8-2004819-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/77add33297b7/ADVS-8-2004819-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/c5e73dc8cce3/ADVS-8-2004819-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/12e1648496f2/ADVS-8-2004819-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/276b773a5072/ADVS-8-2004819-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/4e5685a503b1/ADVS-8-2004819-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/3ec237402b18/ADVS-8-2004819-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/77add33297b7/ADVS-8-2004819-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/c5e73dc8cce3/ADVS-8-2004819-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/12e1648496f2/ADVS-8-2004819-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/276b773a5072/ADVS-8-2004819-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d6/8425867/4e5685a503b1/ADVS-8-2004819-g009.jpg

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本文引用的文献

[1]
Revealing the complexity of ionic liquid-protein interactions through a multi-technique investigation.

Commun Chem. 2020-5-6

[2]
Silica-coated magnetic iron oxide functionalized with hydrophobic polymeric ionic liquid: a promising nanoscale sorbent for simultaneous extraction of antidiabetic drugs from human plasma prior to their quantitation by HPLC.

RSC Adv. 2018-8-29

[3]
Structural, Thermal, and Storage Stability of Hemocyanin in the Presence of Cholinium-Amino Acid-Based Ionic Liquids.

Molecules. 2021-3-19

[4]
Mechanism of Antibacterial Activity of Choline-Based Ionic Liquids (CAGE).

ACS Biomater Sci Eng. 2018-7-9

[5]
Metal-Containing Poly(ionic liquid) Membranes for Antibacterial Applications.

ACS Biomater Sci Eng. 2017-6-12

[6]
Photo-Switchable Nanomechanical Systems Comprising a Nanocontainer (Montmorillonite) and Light-Driven Molecular Jack (Azobenzene-Imidazolium Ionic Liquids) as Drug Delivery Systems; Synthesis, Characterization, and in Vitro Release Studies.

ACS Biomater Sci Eng. 2018-1-8

[7]
The transition from salt-in-water to water-in-salt nanostructures in water solutions of organic ionic liquids relevant for biological applications.

Phys Chem Chem Phys. 2021-1-21

[8]
Protein-avoidant ionic liquid (PAIL)-coated nanoparticles to increase bloodstream circulation and drive biodistribution.

Sci Adv. 2020-11

[9]
Enhancement of Anticancer Efficacy and Tumor Penetration of Sorafenib by Ionic Liquids.

Adv Healthc Mater. 2021-1

[10]
Molecular Sizes and Antibacterial Performance Relationships of Flexible Ionic Liquid Derivatives.

J Am Chem Soc. 2020-11-25

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