Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15 Seccion XVI Tlalpan, 14000, Mexico City, Mexico.
World J Surg. 2010 Jul;34(7):1511-6. doi: 10.1007/s00268-010-0473-9.
Retroperitoneal soft tissue sarcomas (RSTS) are a rare and uncommon entity with a poor 5-year overall survival (OS) of approximately 50%, even though they rarely metastasize. The aim of the present study was to analyze the survival of patients with RSTS treated at our institution.
Patients with RSTS treated between 1990 and 2008 were included. Variables analyzed were age, sex, histological type, TNM stage, tumor size, grade of differentiation, and treatment (surgery, chemotherapy only, radiotherapy only, adjuvant radiotherapy, and best supportive care). R0, R1, and R2 resection were analyzed. Overall survival, recurrence-free survival (RFS), cancer-specific survival (CSS), and survival comparison by stage, grade, and type of resection were analyzed.
Data for 46 patients were analyzed, 20 men and 26 women. Median age was 51.1 years. Surgery with a curative intent was performed in 32 patients, and R0 resection was feasible in 19 (59.4%). The 5- and 10-year OS rates were 47 and 30%, respectively, for the entire group. The median CSS for resected patients was 102 months; the 5-year OS for stages I, III, and IV was 83, 37, and 0%, respectively; the 5-year OS for low histological grade disease and high histological grade disease was 82 and 35%, respectively; and for R0, R1, and R2 resection, the 5-year OS was 81, 56, and 14%, respectively. Median RFS was 79 months.
Incomplete surgical resection, unresectable disease, high histological grade, and advanced TNM stage are associated with a poor survival in patients with RSTS. Complete resection is still the treatment of choice.
腹膜后软组织肉瘤（RSTS）是一种罕见且不常见的疾病，即使很少发生转移，其 5 年总生存率（OS）也仅约为 50%。本研究旨在分析在我院治疗的 RSTS 患者的生存情况。
纳入了 1990 年至 2008 年间接受治疗的 RSTS 患者。分析的变量包括年龄、性别、组织学类型、TNM 分期、肿瘤大小、分化程度和治疗方法（手术、单纯化疗、单纯放疗、辅助放疗和最佳支持治疗）。分析了 R0、R1 和 R2 切除。分析了总生存（OS）、无复发生存（RFS）、癌症特异性生存（CSS）以及根据分期、分级和切除类型的生存比较。
共分析了 46 例患者的数据，其中男性 20 例，女性 26 例。中位年龄为 51.1 岁。32 例患者进行了根治性手术，19 例（59.4%）可行 R0 切除。全组患者的 5 年和 10 年 OS 率分别为 47%和 30%。行切除术患者的中位 CSS 为 102 个月；I、III 和 IV 期患者的 5 年 OS 分别为 83%、37%和 0%；低组织学分级和高组织学分级疾病患者的 5 年 OS 分别为 82%和 35%；R0、R1 和 R2 切除患者的 5 年 OS 分别为 81%、56%和 14%。中位 RFS 为 79 个月。
不完全手术切除、不可切除疾病、高组织学分级和晚期 TNM 分期与 RSTS 患者的不良生存相关。完整切除仍然是治疗的首选。
