Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai, China.
Parasitol Res. 2010 Mar;106(4):967-76. doi: 10.1007/s00436-010-1752-y. Epub 2010 Feb 17.
Apoptosis is a normal process for regulating cellular death of many organisms. Here, we molecularly characterized an inhibitor of apoptosis from Schistosoma japonicum (SjIAP). The transcription of the SjIAP predominantly occurred at the developmental stages in a final host. Functional assay indicated that the SjIAP could inhibit caspase activity either in 293T cell or in schistosome lysates. Additionally, there were differently expressed profiles of the SjIAP in S. japonicum living in different hosts. Our preliminary results suggest that the SjIAP may play important roles in parasitic living and development as well as in the host-parasite interactions, and drug target of SjIAP might be a potential for controlling schistosomiasis.
细胞凋亡是许多生物调节细胞死亡的一种正常过程。在这里，我们从日本血吸虫中鉴定出一种凋亡抑制蛋白（SjIAP）。SjIAP 的转录主要发生在终宿主的发育阶段。功能分析表明，SjIAP 可以抑制 293T 细胞或血吸虫裂解物中的半胱天冬酶活性。此外，SjIAP 在生活在不同宿主的日本血吸虫中的表达谱也不同。我们的初步结果表明，SjIAP 可能在寄生虫的生活和发育以及宿主-寄生虫相互作用中发挥重要作用，SjIAP 的药物靶点可能是控制血吸虫病的一个潜在靶点。
