Hu Wei, Yan Qing, Shen Da-Kang, Liu Feng, Zhu Zhi-Dong, Song Huai-Dong, Xu Xiang-Ru, Wang Zhao-Jun, Rong Yi-Ping, Zeng Ling-Chun, Wu Jian, Zhang Xin, Wang Ju-Jun, Xu Xue-Nian, Wang Sheng-Yue, Fu Gang, Zhang Xiang-Lin, Wang Zhi-Qin, Brindley Paul J, McManus Donald P, Xue Chun-Liang, Feng Zheng, Chen Zhu, Han Ze-Guang
Chinese National Human Genome Center at Shanghai, 351 Guo shou-Jing Road, Shanghai 201203, China.
Nat Genet. 2003 Oct;35(2):139-47. doi: 10.1038/ng1236. Epub 2003 Sep 14.
Schistosoma japonicum causes schistosomiasis in humans and livestock in the Asia-Pacific region. Knowledge of the genome of this parasite should improve understanding of schistosome-host interactions, biomedical aspects of schistosomiasis and invertebrate evolution. We assigned 43,707 expressed sequence tags (ESTs) derived from adult S. japonicum and their eggs to 13,131 gene clusters. Of these, 35% shared no similarity with known genes and 75% had not been reported previously in schistosomes. Notably, S. japonicum encoded mammalian-like receptors for insulin, progesterone, cytokines and neuropeptides, suggesting that host hormones, or endogenous parasite homologs, could orchestrate schistosome development and maturation and that schistosomes modulate anti-parasite immune responses through inhibitors, molecular mimicry and other evasion strategies.
日本血吸虫在亚太地区导致人类和家畜感染血吸虫病。了解这种寄生虫的基因组应能增进对血吸虫与宿主相互作用、血吸虫病的生物医学方面以及无脊椎动物进化的理解。我们将来自日本血吸虫成虫及其虫卵的43707个表达序列标签（EST）归入13131个基因簇。其中，35%与已知基因无相似性，75%此前未在血吸虫中报道过。值得注意的是，日本血吸虫编码了与哺乳动物类似的胰岛素、孕酮、细胞因子和神经肽受体，这表明宿主激素或内源性寄生虫同源物可能调控血吸虫的发育和成熟，并且血吸虫通过抑制剂、分子模拟和其他逃避策略来调节抗寄生虫免疫反应。
