UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095-8353, USA.
Clin Neuropsychol. 2010 Feb;24(2):265-85. doi: 10.1080/13854040903482830.
This study examined the interactive effects of cerebrovascular risks, advancing age, and HIV infection on neurocognition, and explored whether pharmacological treatment of cerebrovascular risk factors attenuated neurocognitive dysfunction. Participants included 98 HIV-seropositive adults (cerebrovascular risk: 23.5%; age > 50: 27.6%). Cerebrovascular risk was associated with slower processing speed even after controlling for age effects (b = -2.071; p =.04), and the interaction of age and cerebrovascular risk was associated with poorer verbal fluency (b = 1.276, p =.002). Participants with pharmacologically untreated cerebrovascular risk demonstrated reduced processing speed, learning/memory, and executive functioning relative to those on medication. Poor cerebrovascular health confers significant risk for HIV+ individuals, and this effect may be of greater consequence than advancing age. The cognitive impact of risk appears to be more pronounced in the absence of adequate pharmacological treatment.
本研究考察了脑血管风险、年龄增长和 HIV 感染对神经认知的交互影响，并探讨了脑血管危险因素的药物治疗是否能减轻神经认知功能障碍。参与者包括 98 名 HIV 阳性成年人（脑血管风险：23.5%；年龄>50 岁：27.6%）。即使在控制了年龄因素的影响后，脑血管风险仍与较慢的处理速度相关（b = -2.071；p =.04），并且年龄和脑血管风险的相互作用与言语流畅性较差相关（b = 1.276，p =.002）。与接受药物治疗的参与者相比，未接受药物治疗的脑血管风险参与者的处理速度、学习/记忆和执行功能均降低。较差的脑血管健康状况对 HIV 阳性个体构成重大风险，其影响可能比年龄增长更为严重。在缺乏充分药物治疗的情况下，风险的认知影响似乎更为明显。
