Ríos Antonio, Martínez-Alarcón Laura, Sánchez José, Jarvis Nicholas, Guzmán Dolores, Parrilla Pascual, Ramírez Pablo
Regional Transplant Center, Health Council of the Autonomous Community of Murcia, Spain.
Int J Artif Organs. 2010 Jan;33(1):30-9.
The objective of this paper is to analyze the attitude toward xenotransplantation and to determine the variables that influence this attitude in the population of southeast Spain who were born in Eastern European countries.
A random sample was taken of natives from Eastern Europe residing in southeast Spain (n=320). The sample was obtained randomly between November 2005 and April 2006 and stratified according to the respondents' nationality. Attitude was evaluated using a validated questionnaire which was self-administered and completed anonymously. The control group was a random sample of the native Spanish population (n=250). The statistical analysis used included Student's t-test, the chi-square test, Fisher's exact test, and a logistic regression analysis.
The questionnaire completion rate was 83% (n=267). Regarding the use of animal organs for transplantation in humans, if the outcome were similar to that achieved when using human organs, 43% (n=114) would be in favor, 32% (n=86) undecided, and the remaining 25% (n=67) would be against it. This attitude is less favorable than in the control group (43% versus 74%, p<0.001). The attitude was related to the following factors: 1) the country of origin (p<0.001); 2) participation in social help activities (p<0.001); 3) discussion on organ donation and transplantation within the family (p=0.005); 4) previous experience of organ donation and transplantation (p=0.002); 5) the respondent's religion (p=0.002); 6) knowing that one's partner had a favorable attitude toward transplantation (p<0.001); 7) the respondent's belief that he or she might need a transplant in the future (p<0.001); 8) the attitude toward human donation, both from cadaver (p<0.001) and living (p<0.001) donors. The following were also independent variables in the subsequent multivariate analysis: 1) favorable attitude toward cadaver organ donation (OR=4.998); 2) previous experience of donation (0R=2.857); 3) partner's attitude against transplantation (OR=0.079); and 4) attitude toward living donation (OR=12. 703).
The attitude toward xenotransplantation is less positive among Eastern Europeans living in Spain than in the native Spanish population and is influenced by many psychosocial factors that are mainly related to human organ donation.
本文旨在分析对异种移植的态度，并确定影响西班牙东南部出生于东欧国家人群这一态度的变量。
对居住在西班牙东南部的东欧本地人进行随机抽样（n = 320）。该样本于2005年11月至2006年4月间随机抽取，并根据受访者的国籍进行分层。使用经过验证的问卷对态度进行评估，问卷由受访者自行填写并匿名完成。对照组是西班牙本地人群的随机样本（n = 250）。所使用的统计分析包括学生t检验、卡方检验、费舍尔精确检验和逻辑回归分析。
问卷完成率为83%（n = 267）。关于在人类移植中使用动物器官，如果结果与使用人类器官时相似，43%（n = 114）会表示赞成，32%（n = 86）不确定，其余25%（n = 67）会反对。这种态度不如对照组积极（43%对74%，p<0.001）。该态度与以下因素有关：1）原籍国（p<0.001）；2）参与社会救助活动（p<0.001）；3）家庭内部关于器官捐赠和移植的讨论（p = 0.005）；4）器官捐赠和移植的既往经历（p = 0.002）；5）受访者的宗教信仰（p = 0.002）；6）知道自己的伴侣对移植持赞成态度（p<0.001）；7）受访者认为自己未来可能需要移植（p<0.001）；8）对来自尸体（p<0.001）和活体（p<0.001）捐赠者的人类捐赠的态度。以下也是后续多变量分析中的独立变量：1）对尸体器官捐赠的赞成态度（OR = 4.998）；2）捐赠的既往经历（OR = 2.857）；3）伴侣对移植的反对态度（OR = 0.079）；4）对活体捐赠的态度（OR = 12.703）。
居住在西班牙的东欧人对异种移植的态度不如西班牙本地人积极，并且受到许多主要与人体器官捐赠相关的社会心理因素的影响。
