Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, NV 89154, USA.
J Biophotonics. 2010 Jun;3(5-6):356-67. doi: 10.1002/jbio.200900095.
The blood-brain barrier (BBB) poses a significant impediment for the delivery of therapeutic drugs into the brain. This is particularly problematic for the treatment of malignant gliomas which are characterized by diffuse infiltration of tumor cells into normal brain where they are protected by a patent BBB. Selective disruption of the BBB, followed by administration of anti-cancer agents, represents a promising approach for the elimination of infiltrating glioma cells. A summary of the techniques (focused ultrasound, photodynamic therapy and photochemical internalization) for site-specific opening of the BBB will be discussed in this review. Each approach is capable of causing localized and transient opening of the BBB with minimal damage to surrounding normal brain as evidenced from magnetic resonance images and histology.
血脑屏障（BBB）对治疗药物进入大脑构成了重大障碍。对于恶性脑胶质瘤的治疗尤其如此，这些肿瘤的特点是肿瘤细胞弥漫性浸润到正常脑组织中，而正常脑组织的 BBB 是完好的。选择性破坏 BBB，然后给予抗癌药物，是消除浸润性脑胶质瘤细胞的一种很有前途的方法。本文综述了用于 BBB 特异性开放的技术（聚焦超声、光动力疗法和光化学内化）。每种方法都能够在最小化对周围正常脑组织损伤的情况下，实现局部和短暂的 BBB 开放，这从磁共振图像和组织学中都可以得到证实。
