Semyachkina-Glushkovskaya Oxana, Terskov Andrey, Khorovodov Alexander, Telnova Valeria, Blokhina Inna, Saranceva Elena, Kurths Jürgen
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Institute of Physics, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany.
Pharmaceutics. 2022 Nov 26;14(12):2612. doi: 10.3390/pharmaceutics14122612.
Photodynamic therapy (PDT) is a promising add-on therapy to the current standard of care for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT effects involves the PDT-induced generation of a singlet oxygen in the GBM cells, which causes tumor cell death and microvasculature collapse. Recently, new vascular mechanisms of PDT associated with opening of the blood-brain barrier (OBBB) and the activation of functions of the meningeal lymphatic vessels have been discovered. In this review, we highlight the emerging trends and future promises of immunotherapy for brain tumors and discuss PDT-OBBB as a new niche and an important informative platform for the development of innovative pharmacological strategies for the modulation of brain tumor immunity and the improvement of immunotherapy for GBM.
光动力疗法（PDT）是胶质母细胞瘤（GBM）患者当前标准治疗的一种有前景的辅助疗法。关于抗癌PDT效应的传统解释涉及PDT诱导GBM细胞中产生单线态氧，这会导致肿瘤细胞死亡和微血管塌陷。最近，发现了与血脑屏障开放（OBBB）和脑膜淋巴管功能激活相关的PDT新血管机制。在本综述中，我们强调了脑肿瘤免疫疗法的新趋势和未来前景，并将PDT-OBBB作为一个新的细分领域和重要的信息平台进行讨论，以开发用于调节脑肿瘤免疫和改善GBM免疫疗法的创新药理学策略。
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