Division of Plastic Surgery, University of São Paulo Medical School, São Paulo, Brazil.
Tissue Eng Part C Methods. 2010 Oct;16(5):1183-9. doi: 10.1089/ten.TEC.2009.0824.
A resorbable collagen matrix with recombinant human bone morphogenetic protein (rhBMP-2) was compared with traditional iliac crest bone graft for the closure of alveolar defects during secondary dental eruption.
Sixteen patients with unilateral cleft lip and palate, aged 8 to 12 years, were selected and randomly assigned to group 1 (rhBMP-2) or group 2 (iliac crest bone graft). Computed tomography was performed to assess both groups preoperatively and at months 6 and 12 postoperatively. Bone height and defect volume were calculated through Osirix Dicom Viewer (Pixmeo, Apple Inc.). Overall morbidity was recorded.
Preoperative and follow-up examinations revealed progressive alveolar bone union in all patients. For group 1, final completion of the defect with a 65.0% mean bone height was detected 12 months postoperatively. For group 2, final completion of the defect with an 83.8% mean bone height was detected 6 months postoperatively. Dental eruption routinely occurred in both groups. Clinical complications included significant swelling in three group 1 patients (37.5%) and significant donor-site pain in seven group 2 patients (87.5%).
For this select group of patients with immature skeleton, rhBMP-2 therapy resulted in satisfactory bone healing and reduced morbidity compared with traditional iliac crest bone grafting.
在二次牙萌出期间，我们将可吸收胶原基质与重组人骨形态发生蛋白（rhBMP-2）与传统的髂嵴骨移植进行了比较，以闭合牙槽骨缺损。
选择了 16 名单侧唇腭裂患者，年龄在 8 至 12 岁之间，并将其随机分配到第 1 组（rhBMP-2）或第 2 组（髂嵴骨移植）。在术前和术后 6 个月和 12 个月，使用计算机断层扫描（CT）对两组患者进行评估。通过 Osirix Dicom Viewer（Pixmeo，Apple Inc.）计算骨高度和缺损体积。记录总体发病率。
所有患者的术前和随访检查均显示出牙槽骨的逐渐愈合。第 1 组患者的平均骨高度为 65.0%，12 个月后可最终完成骨缺损。第 2 组患者的平均骨高度为 83.8%，6 个月后可最终完成骨缺损。两组患者的牙齿萌出均为常规发生。临床并发症包括 3 名第 1 组患者（37.5%）出现显著肿胀和 7 名第 2 组患者（87.5%）出现显著供区疼痛。
对于这组骨骼未成熟的患者，rhBMP-2 治疗与传统的髂嵴骨移植相比，可获得令人满意的骨愈合效果，并降低发病率。
