Genetic Counseling Program, Arcadia University, Glenside, Pennsylvania, USA.
Epilepsia. 2010 Sep;51(9):1874-7. doi: 10.1111/j.1528-1167.2009.02507.x.
We investigated estimated offspring risk among people with epilepsy and factors important in the family-planning process. Data were collected for 88 participants using a questionnaire assessing perceived risk of offspring to develop epilepsy, importance of factors in the reproductive decision-making process, decision to have fewer children, and association between risk perception and family planning decisions. Thirty-four percent of participants had fewer children because of their epilepsy. Concerns about the ability to care for a child (p < 0.0001) and passing epilepsy onto a child (p = 0.003) were associated with the decision to have fewer children. The mean estimated risk of offspring to develop epilepsy was 26%, a 4-fold increase over estimated population risks. Genetic counseling may be beneficial for people with epilepsy, given the considerable overestimation of offspring risk.
我们调查了癫痫患者的子女发病风险以及生育计划过程中的重要因素。通过问卷调查收集了 88 名参与者的数据，评估了他们对子女患癫痫风险的认知、生育决策过程中各因素的重要性、生育子女数量的决策以及风险认知与生育计划决策之间的关系。34%的参与者因癫痫而生育子女数量较少。担心照顾孩子的能力（p<0.0001）和将癫痫遗传给孩子（p=0.003）与生育子女数量较少的决策有关。子女患癫痫的平均预估风险为 26%，是人群预估风险的 4 倍。鉴于对子女发病风险的严重高估，遗传咨询可能对癫痫患者有益。
