Exp Dermatol. 2010 May;19(5):464-6. doi: 10.1111/j.1600-0625.2010.01067.x. Epub 2010 Feb 16.
IL-31 represents a novel cytokine involved in pruritic skin diseases including atopic dermatitis (AD). We, therefore, aimed at investigating IL-31 levels in chronic spontaneous urticaria (CU). We included 46 patients with CU, 26 non-atopic skin healthy subjects as negative and 28 patients with AD as positive controls. IL-31 serum levels were analysed using commercial ELISA kit. IL-31 serum levels were higher in patients with CU compared to healthy controls (P < 0.001), but lower compared to patients with AD (P < 0.001). There was no difference in IL-31 serum levels in autologous serum skin test positive or negative CU patients and patients with infectious trigger factors including helicobacter pylori infection. IL-31 serum levels may play a role in the pathophysiology of CU. This is supported by the finding that not all patients with CU respond to antihistamine treatment but to the treatment with immunosuppressive drugs.
IL-31 代表一种新型细胞因子，与特应性皮炎（AD）等瘙痒性皮肤病有关。因此，我们旨在研究慢性自发性荨麻疹（CU）中的 IL-31 水平。我们纳入了 46 例 CU 患者、26 例非特应性皮肤健康对照者作为阴性对照和 28 例 AD 患者作为阳性对照。采用商业 ELISA 试剂盒分析 IL-31 血清水平。与健康对照者相比，CU 患者的 IL-31 血清水平更高（P<0.001），但与 AD 患者相比则较低（P<0.001）。在自体血清皮肤试验阳性或阴性的 CU 患者和存在幽门螺杆菌感染等感染性触发因素的患者中，IL-31 血清水平无差异。IL-31 血清水平可能在 CU 的病理生理学中发挥作用。这一发现得到了支持，即并非所有 CU 患者均对抗组胺治疗有反应，而是对免疫抑制药物治疗有反应。
