Department of Internal Medicine, University Hospital San Martino, University of Genoa, Genoa, Italy.
Clin Exp Dermatol. 2011 Jan;36(1):85-7. doi: 10.1111/j.1365-2230.2010.03914.x.
Serum neopterin may be considered a diagnostic marker of the degree of activation of the immune system. This preliminary study was performed to measure serum neopterin levels in patients with acute spontaneous urticaria (ASU), chronic spontaneous urticaria (CSU) and atopic dermatitis (AD). In total, 180 patients [96 men, 84 women; mean age 23.1 years; 41 with spontaneous urticaria (13 ASU and 28 CSU), 48 with AD] and 96 healthy controls were enrolled in the study. Patients with ASU had the highest neopterin levels, and all three groups of patients (ASU, CSU and AD) had higher values than normal subjects. This preliminary study demonstrates that serum neopterin could be a biomarker of immune activation in patients with SU or AD.
血清中新蝶呤可被视为免疫系统激活程度的诊断标志物。本初步研究旨在测量急性自发性荨麻疹（ASU）、慢性自发性荨麻疹（CSU）和特应性皮炎（AD）患者的血清中新蝶呤水平。共纳入 180 例患者[96 例男性，84 例女性；平均年龄 23.1 岁；41 例自发性荨麻疹（13 例 ASU 和 28 例 CSU），48 例特应性皮炎]和 96 例健康对照者。ASU 患者的新蝶呤水平最高，所有三组患者（ASU、CSU 和 AD）的新蝶呤水平均高于正常对照者。本初步研究表明，血清中新蝶呤可能是 SU 或 AD 患者免疫激活的生物标志物。
Zotero 插件