J-LEAPS 免疫原促进树突状细胞前体向 IL12 产生树突状细胞的成熟。
Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens.
机构信息
Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA.
出版信息
Cell Immunol. 2010;262(1):1-5. doi: 10.1016/j.cellimm.2010.01.003. Epub 2010 Feb 1.
Abstract
LEAPS (ligand epitope antigen presentation system) vaccines consist of a peptide containing a major histocompatibility antigen binding peptide conjugated to an immune cell binding ligand (ICBL) such as the 'J' peptide from beta-2-microglobulin. Treatment of monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD (containing a peptide from gD of herpes simplex virus type 1) or JH (with a peptide from HIV p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing dendritic cells. JgD-dendritic cells supported allotypic activation of T cells to produce Th1-related cytokines.
摘要
LEAPS（配体表位抗原呈递系统）疫苗由含有主要组织相容性抗原结合肽的肽与免疫细胞结合配体（如β-2-微球蛋白的“J”肽）缀合而成。用 JgD（含有单纯疱疹病毒 1 型 gD 肽）或 JH（含有 HIV p17 gag 蛋白肽）处理单核细胞、单核细胞加 GMCSF 或单核细胞加 GMCSF 和 IL4，足以促进它们成熟为产生白细胞介素 12 的树突状细胞。JgD-树突状细胞支持同种型激活 T 细胞产生 Th1 相关细胞因子。
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