细胞和血浆促凝活性对纤维蛋白网络的影响。
Influence of cellular and plasma procoagulant activity on the fibrin network.
机构信息
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC 27599-7525, USA.
出版信息
Thromb Res. 2010 Apr;125 Suppl 1:S35-7. doi: 10.1016/j.thromres.2010.01.033. Epub 2010 Feb 16.
Abstract
At the nexus of cellular and plasma procoagulant activities lies fibrin, which is necessary to provide a clot's structural support. Abnormalities in fibrin network formation or function can result in either bleeding or thrombotic complications. Understanding relationships between procoagulant activity and normal fibrin formation, as well as pathophysiologic mechanisms leading to abnormal fibrin deposition, is essential for the continued development of hemostatic and antithrombotic therapies.
摘要
在细胞和血浆促凝活性的交汇点是纤维蛋白，它是提供血栓结构支撑所必需的。纤维蛋白网络形成或功能的异常可导致出血或血栓并发症。了解促凝活性与正常纤维蛋白形成之间的关系，以及导致异常纤维蛋白沉积的病理生理机制，对于继续开发止血和抗血栓治疗至关重要。
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