缺氧诱导因子-1 依赖性血管生成和血管重构机制。
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.
机构信息
Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 N. Broadway, Baltimore, MD 21205, USA.
出版信息
Cardiovasc Res. 2010 May 1;86(2):236-42. doi: 10.1093/cvr/cvq045. Epub 2010 Feb 17.
Abstract
The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.
摘要
脉管系统将氧气和营养物质输送到脊椎动物机体的每个细胞。缺氧诱导因子 1（HIF-1）是缺氧/缺血性血管反应的主要调节因子，驱动涉及血管反应性、血管生成、动脉生成以及骨髓源性血管生成细胞的动员和归巢的数百个基因的转录激活。这篇综述将重点介绍 HIF-1 在血管稳态中的关键作用、HIF-1 在血管疾病中的作用以及在临床前模型中针对 HIF-1 进行治疗的最新进展。
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