呼吸道合胞病毒附着蛋白中央无糖基化区域内中和表位的鉴定及其与人血清的反应原性
Identification of and human serum reactogenicity to neutralizing epitopes within the central unglycosylated region of the respiratory syncytial virus attachment protein.
作者信息
Murata Yoshihiko, Lightfoote Paula M, Falsey Ann R, Walsh Edward E
机构信息
Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA.
出版信息
Clin Vaccine Immunol. 2010 Apr;17(4):695-7. doi: 10.1128/CVI.00432-09. Epub 2010 Feb 17.
Abstract
We identified two overlapping neutralizing epitopes within residues 151 to 172 of the central unglycosylated region of the respiratory syncytial virus (RSV) attachment protein. In approximately 40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of > or =4-fold increases in IgG response between acute- and convalescent-phase sera.
摘要
我们在呼吸道合胞病毒（RSV）附着蛋白中心未糖基化区域的151至172位残基内鉴定出两个重叠的中和表位。在约40%感染了A亚型RSV的住院及门诊成人中，这些相邻残基是急性期和恢复期血清之间IgG反应增加≥4倍的靶点。
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本文引用的文献
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Antiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein.人呼吸道合胞病毒附着（G）糖蛋白非糖基化中央亚结构域的抗病毒活性及结构特征
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Monoclonal antibody neutralization escape mutants of respiratory syncytial virus with unique alterations in the attachment (G) protein.呼吸道合胞病毒的单克隆抗体中和逃逸突变体，其附着（G）蛋白有独特改变。
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Antigenic structure, evolution and immunobiology of human respiratory syncytial virus attachment (G) protein.人呼吸道合胞病毒附着（G）蛋白的抗原结构、进化及免疫生物学
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Analysis of linear epitopes recognised by the primary human antibody response to a variable region of the attachment (G) protein of respiratory syncytial virus.对呼吸道合胞病毒附着（G）蛋白可变区的主要人类抗体反应所识别的线性表位的分析。
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Analysis of the human serological immune response to a variable region of the attachment (G) protein of respiratory syncytial virus during primary infection.初次感染期间人体对呼吸道合胞病毒黏附（G）蛋白可变区的血清学免疫反应分析。
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