Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
J Immunol. 2010 Mar 15;184(6):2825-38. doi: 10.4049/jimmunol.0902168. Epub 2010 Feb 17.
In this study, we demonstrate complex networks of CD8 T cell cross-reactivities between influenza A virus and EBV in humans and between lymphocytic choriomeningitis virus and vaccinia virus in mice. We also show directly that cross-reactive T cells mediate protective heterologous immunity in mice. Subsets of T cell populations reactive with one epitope cross-reacted with either of several other epitopes encoded by the same or the heterologous virus. Human T cells specific to EBV-encoded BMLF1(280-288) could be cross-reactive with two influenza A virus or two other EBV epitopes. Mouse T cells specific to the vaccinia virus-encoded a11r(198-205) could be cross-reactive with three different lymphocytic choriomeningitis virus, one Pichinde virus, or one other vaccinia virus epitope. Patterns of cross-reactivity differed among individuals, reflecting the private specificities of the host's immune repertoire and divergence in the abilities of T cell populations to mediate protective immunity. Defining such cross-reactive networks between commonly encountered human pathogens may facilitate the design of vaccines.
在这项研究中，我们展示了人类中流感病毒 A 和 EBV 之间以及小鼠中淋巴细胞性脉络丛脑膜炎病毒和牛痘病毒之间的 CD8 T 细胞交叉反应的复杂网络。我们还直接表明，交叉反应性 T 细胞介导了小鼠中的保护性异源免疫。与一个表位反应的 T 细胞亚群与同一或异源病毒编码的几个其他表位发生交叉反应。针对 EBV 编码的 BMLF1(280-288)的人类 T 细胞可能与两种流感病毒或两种其他 EBV 表位发生交叉反应。针对牛痘病毒编码的 a11r(198-205)的小鼠 T 细胞可能与三种不同的淋巴细胞性脉络丛脑膜炎病毒、一种皮钦德病毒或另一种牛痘病毒表位发生交叉反应。交叉反应的模式在个体之间存在差异，反映了宿主免疫库的私人特异性以及 T 细胞群体介导保护性免疫的能力的差异。定义这些常见人类病原体之间的交叉反应网络可能有助于疫苗的设计。
