Paulus W J, Sys S U, Heyndrickx G R, Andries E
Cardiovascular Center, Aalst, Belgium.
J Am Coll Cardiol. 1991 May;17(6):1263-9. doi: 10.1016/s0735-1097(10)80133-0.
The effects of balloon aortic valvuloplasty on orifice variability of the stenotic sclerocalcific aortic valve were evaluated by hemodynamic measurements of aortic valve function in 14 patients before balloon aortic valvuloplasty, during nitroprusside infusion before valvuloplasty, 48 h after valvuloplasty and during nitroprusside infusion 48 h after valvuloplasty. Aortic valve function was assessed by aortic valve area calculations with use of the Gorlin and Cannon formulas. Nitroprusside infusion before balloon aortic valvuloplasty caused no change in mean aortic valve gradient but a significant increase in mean aortic transvalvular flow from 186 +/- 46 to 202 +/- 61 ml/s (p less than 0.05), in Gorlin aortic valve area from 0.49 +/- 0.17 to 0.53 +/- 0.21 cm2 (p less than 0.05) and in Cannon aortic valve area from 0.45 +/- 0.18 to 0.49 +/- 0.22 cm2 (p less than 0.05). Nitroprusside infusion 48 h after valvuloplasty induced no change in mean aortic valve gradient but a significant increase in mean aortic transvalvular flow from 214 +/- 61 to 254 +/- 78 ml/s (p less than 0.005), in Gorlin aortic valve area from 0.71 +/- 0.25 to 0.83 +/- 0.32 cm2 (p less than 0.01) and in Cannon aortic valve area from 0.78 +/- 0.33 to 0.88 +/- 0.40 cm2 (p less than 0.05). Forty-eight hours after valvuloplasty, nitroprusside infusion induced a larger increase (40 +/- 40 ml/s) in mean transvalvular flow than before valvuloplasty (16 +/- 27 ml/s; p less than 0.05) and a larger increase (0.12 +/- 0.14 cm2) in Gorlin aortic valve area than before valvuloplasty (0.05 +/- 0.07 cm2; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
通过对14例患者在球囊主动脉瓣成形术前、瓣膜成形术前硝普钠输注期间、瓣膜成形术后48小时以及瓣膜成形术后48小时硝普钠输注期间的主动脉瓣功能进行血流动力学测量，评估球囊主动脉瓣成形术对狭窄性硬化性主动脉瓣瓣口变异性的影响。使用戈林（Gorlin）公式和坎农（Cannon）公式计算主动脉瓣面积来评估主动脉瓣功能。球囊主动脉瓣成形术前输注硝普钠，平均主动脉瓣压差无变化，但平均主动脉跨瓣血流量从186±46ml/s显著增加至202±61ml/s（p<0.05），戈林主动脉瓣面积从0.49±0.17cm²增加至0.53±0.21cm²（p<0.05），坎农主动脉瓣面积从0.45±0.18cm²增加至0.49±0.22cm²（p<0.05）。瓣膜成形术后48小时输注硝普钠，平均主动脉瓣压差无变化，但平均主动脉跨瓣血流量从214±61ml/s显著增加至254±78ml/s（p<0.005），戈林主动脉瓣面积从0.71±0.25cm²增加至0.83±0.32cm²（p<0.01），坎农主动脉瓣面积从0.78±0.33cm²增加至0.88±0.40cm²（p<0.05）。瓣膜成形术后48小时，硝普钠输注引起的平均跨瓣血流量增加量（40±40ml/s）大于瓣膜成形术前（16±27ml/s；p<0.05），戈林主动脉瓣面积增加量（0.12±0.14cm²）大于瓣膜成形术前（0.05±0.07cm²；p<0.05）。（摘要截取自250字）
