Isner J M, Salem D N, Desnoyers M R, Fields C D, Halaburka K R, Slovenkai G A, Hougen T J, Eichhorn E J, Rosenfield K
Department of Medicine, New England Medical Center/Tufts University School of Medicine, Boston, Massachusetts 02111.
Am J Cardiol. 1988 Mar 1;61(8):583-9. doi: 10.1016/0002-9149(88)90769-2.
A dual balloon technique was studied in 16 patients with aortic stenosis in whom results with a single balloon (up to 20 mm, 5.5 cm or 25 mm, 3.0 cm in diameter and length, respectively) were judged to be suboptimal. Dual balloon valvuloplasty was performed using 2 balloons advanced and inflated simultaneously across the stenotic aortic valve orifice. For the group as a whole, the average peak transvalvular gradient was reduced from 79 +/- 8 to 57 +/- 7 mm Hg (mean +/- standard error) using a single balloon (p less than 0.0005), and reduced further to 36 +/- 4 mm Hg using dual balloons (p less than 0.0005 compared with single balloon results). Similarly, calculated aortic valve orifice area was increased from 0.45 +/- 0.04 to 0.57 +/- 0.05 cm2 using a single balloon (p less than 0.0005), and further increased to 0.77 +/- 0.06 cm2 using dual balloons (p less than 0.0005). Dual balloon dilation caused no complications directly attributable to the use of 2 balloons, including no exacerbation of aortic regurgitation. These results suggest that dual balloon valvuloplasty is safe and efficacious in selected patients with aortic stenosis.
对16例主动脉瓣狭窄患者进行了双球囊技术研究，这些患者单球囊扩张术（球囊直径分别达20mm、长5.5cm或直径25mm、长3.0cm）的效果被判定为欠佳。双球囊瓣膜成形术是通过同时推进并充盈2个球囊穿过狭窄的主动脉瓣口来进行的。对于整个研究组，使用单球囊时平均跨瓣峰值压差从79±8降至57±7mmHg（均值±标准误）（p<0.0005），使用双球囊时进一步降至36±4mmHg（与单球囊结果相比，p<0.0005）。同样，计算得到的主动脉瓣口面积使用单球囊时从0.45±0.04增加至0.57±0.05cm²（p<0.0005），使用双球囊时进一步增加至0.77±0.06cm²（p<0.0005）。双球囊扩张未引起任何直接归因于使用2个球囊的并发症，包括主动脉瓣反流未加重。这些结果表明，双球囊瓣膜成形术在选定的主动脉瓣狭窄患者中是安全有效的。
