甲状腺乳头状癌中的 HLA-DR 相关性。
HLA-DR association in papillary thyroid carcinoma.
机构信息
Endocrinology and metabolism research centre, Tehran university of medical sciences, Tehran, Iran.
出版信息
Dis Markers. 2010;28(1):49-53. doi: 10.3233/DMA-2010-0683.
OBJECTIVE
Papillary thyroid carcinoma (PTC) is the most frequent types of thyroid malignancies. Several genes may be involved in susceptibility of thyroid cancer including Human Leukocyte Antigens (HLA). The association of thyroid carcinoma with HLA alleles has been previously studied in other populations and certain HLA alleles were shown to be either predisposing or protective. The aim of this study was to determine the association between HLA-DR and papillary thyroid carcinoma in an Iranian population.
DESIGN
HLA-DR antigen frequencies were determined in patients with papillary thyroid carcinoma (N=70) and non-related healthy controls (N=180) using PCR -SSP.
MAIN OUTCOME
We found that HLA-DRB1*04 frequency was significantly higher in our patients compared to the controls [P=0.02, OR; 1.9, 95% CI (1.04-3.57)].
CONCLUSIONS
Our results revealed HLA-DRB1*04 as predisposing factor in papillary thyroid carcinoma in Iranian population. This confirms the previous findings for associations between HLA-DRB1 and differentiated carcinomas in other populations.
目的
甲状腺癌是最常见的甲状腺恶性肿瘤。几种基因可能与甲状腺癌的易感性有关，包括人类白细胞抗原（HLA）。以前已经在其他人群中研究了甲状腺癌与 HLA 等位基因的关联，某些 HLA 等位基因被证明具有易感性或保护性。本研究旨在确定 HLA-DR 与伊朗人群中甲状腺乳头状癌的关系。
设计
使用 PCR-SSP 在甲状腺乳头状癌患者（N=70）和非相关健康对照者（N=180）中确定 HLA-DR 抗原频率。
主要结果
与对照组相比，我们发现患者中 HLA-DRB1*04 频率明显更高[P=0.02，OR；1.9，95%CI（1.04-3.57）]。
结论
我们的结果显示 HLA-DRB1*04 是伊朗人群中甲状腺乳头状癌的易感因素。这证实了以前在其他人群中发现的 HLA-DRB1 与分化型癌之间的关联。
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