[人类白细胞抗原与甲状腺癌]

[HLA and thyroid cancer].

作者信息

Dralle H, Robin-Winn M, Reilmann L, Laue A, Török M

出版信息

Klin Wochenschr. 1986 Jun 2;64(11):522-5. doi: 10.1007/BF01713060.

Abstract

HLA typing was performed in 51 patients to analyse the pathogenetic background of differentiated and medullary thyroid carcinomas. A higher incidence of Bw62 and DR5 was observed in patients with papillary carcinoma (n = 24), DRw6 antigen in follicular carcinoma (n = 13), and DR3 antigen in patients with medullary carcinoma (n = 11). The DR3 antigen was present in one of two patients with a familial history of medullary thyroid carcinoma. Therefore, HLA typing is not suitable as a screening method for the detection of early thyroid carcinoma.

摘要

对51例患者进行了HLA分型，以分析分化型和髓样甲状腺癌的发病背景。在乳头状癌患者（n = 24）中观察到Bw62和DR5的发生率较高，在滤泡状癌患者（n = 13）中观察到DRw6抗原发生率较高，在髓样癌患者（n = 11）中观察到DR3抗原发生率较高。在有甲状腺髓样癌家族史的两名患者中，有一名存在DR3抗原。因此，HLA分型不适用于作为早期甲状腺癌检测的筛查方法。