Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
J Alzheimers Dis. 2010;20(2):491-500. doi: 10.3233/JAD-2010-1383.
To investigate whether vascular risk affects the progression of Alzheimer's disease (AD), 415 AD patients aged 65 years old and over without cerebrovascular diseases were enrolled and administered with a structured interview to assess demography, vascular risk factors, and cognitive and functional status at baseline, and 324 AD patients were followed up annually for 5 years. A mixed random effects regression model was used to identify the association between vascular risk, individual vascular risk factors, and the progression of AD. After adjusting for confounding factors, AD patients with vascular risk had faster cognitive and functional decline rates than the subjects without such risk factors. Individual vascular risk factors including hypertension and diabetes mellitus, transient ischemic attack and cerebrovascular accident during the follow-up were independently associated with the progression of AD. Our findings suggest that vascular risk aggravates the progression of AD and may be involved in the etiologic process of AD. As such, control of vascular risk may slow down the progression of AD.
为了研究血管风险是否会影响阿尔茨海默病（AD）的进展，我们招募了 415 名年龄在 65 岁及以上且没有脑血管疾病的 AD 患者，并对他们进行了结构化访谈，以评估人口统计学、血管风险因素以及基线时的认知和功能状态，并且对 324 名 AD 患者进行了每年一次的为期 5 年的随访。我们使用混合随机效应回归模型来确定血管风险、个体血管风险因素与 AD 进展之间的关联。在调整了混杂因素后，患有血管风险的 AD 患者的认知和功能下降速度比没有这些风险因素的患者更快。个体血管风险因素，包括高血压和糖尿病、随访期间的短暂性脑缺血发作和脑血管意外，与 AD 的进展独立相关。我们的研究结果表明，血管风险会加重 AD 的进展，并且可能参与 AD 的发病过程。因此，控制血管风险可能会减缓 AD 的进展。
