IRCCS Santa Lucia Foundation, Rome, Italy.
J Alzheimers Dis. 2010;20(2):501-7. doi: 10.3233/JAD-2010-1384.
In this study, we assess white matter microstructural deficit correlates of apathy level in 20 patients with amnestic mild cognitive impairment by means of diffusion tensor imaging. Mean diffusivity correlated positively with apathy level in the right temporal portion of the uncinate, middle longitudinal and inferior longitudinal fasciculi and in the parathalamic white matter, the fornix and the posterior cingulum of the right hemisphere. Fractional anisotropy results confirmed evidence of disconnection associated with apathy in all white matter areas except the middle longitudinal fasciculus. These results support the view that alterations in the neural mechanisms underlying apathy level occur in the early phase of degenerative dementias.
在这项研究中，我们通过弥散张量成像评估了 20 名遗忘型轻度认知障碍患者的白质微观结构缺陷与淡漠水平的相关性。在右侧钩束、额上纵束和下纵束以及丘脑旁白质、穹窿和右侧后扣带回的颞部、中间和下部分，平均弥散率与淡漠水平呈正相关。各向异性分数结果证实了除额上纵束外，所有白质区域与淡漠相关的连接中断的证据。这些结果支持了这样一种观点，即在退行性痴呆的早期阶段，与淡漠水平相关的神经机制发生了改变。
