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干眼病和正常受试者的改良泪液分泌试验:睁眼与闭眼、1 分钟与 5 分钟试验。

A modified Schirmer test in dry eye and normal subjects: open versus closed eye and 1-minute versus 5-minute tests.

机构信息

Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Cornea. 2010 Apr;29(4):384-7. doi: 10.1097/ICO.0b013e3181ba6ef3.

Abstract

OBJECTIVE

To assess the results of 1-minute and 5-minute Schirmer test (ST) when eyes are open (STo) and closed (STc) in normal subjects and patients with dry eye disease.

METHODS

In a comparative, observational case series study, 34 normal volunteers (group 1) and 34 patients with dry eye disease (DED) associated with Sjogren syndrome (group 2) were included in the study. STo and STc for 1 minute and 5 minutes were performed separately for all subjects with an interval of at least 24 hours using Whatman No. 41 (5 × 60 mm) with bended end of the paper inserted into the lateral side of the lower conjunctival fornix.

RESULTS

In group 1, there were 19 females and 15 males with a mean age of 20.8 years (range 18 to 23 years). In group 2, there were 29 females and 5 males with a mean age of 53.7 years (range 35 to 75 years). Mean value of STc was significantly less than STo in both 1 minute and 5 minutes in both groups. One-minute STo and STc showed significantly less wetting than the 5-minute test in both healthy and patients with DED. Normal distribution was observed for all the values. A significant correlation between 1-minute and 5-minute tests in both STo and STc were found in the two groups. Therefore, two equations were proposed to calculate the 5-minute from 1-minute ST in each group. Statistical analysis did not provide a reliable equation for calculating the standard ST (5-minute STo) from the most comfortable state (1-minute STc).

CONCLUSION

Faster and more comfortable ST (1-minute) is a reliable test to calculate the 5-minute ST in both open and closed eyes, using the provided equations. The 1-minute STc is not a reliable test to calculate the 5-minute STo.

摘要

目的

评估正常人和干眼症患者睁眼(STo)和闭眼(STc)时 1 分钟和 5 分钟 Schirmer 试验(ST)的结果。

方法

在一项比较性、观察性病例系列研究中,纳入 34 名正常志愿者(第 1 组)和 34 名干燥综合征相关性干眼症(DED)患者(第 2 组)。使用带有弯曲端的 Whatman No. 41(5×60mm),将纸的一端插入下穹隆外侧,对所有受试者分别进行 1 分钟和 5 分钟的 STo 和 STc 测量,两次测量之间至少间隔 24 小时。

结果

第 1 组中,女性 19 名,男性 15 名,平均年龄为 20.8 岁(18 至 23 岁)。第 2 组中,女性 29 名,男性 5 名,平均年龄为 53.7 岁(35 至 75 岁)。两组中,1 分钟和 5 分钟时,STc 的平均值均明显小于 STo。在健康人和 DED 患者中,1 分钟 STo 和 STc 的湿化量均明显小于 5 分钟测试。所有值均呈正态分布。两组中,1 分钟和 5 分钟的 STo 和 STc 之间均存在显著相关性。因此,为每组提出了两个从 1 分钟 ST 计算 5 分钟 ST 的方程。统计分析没有为从最舒适状态(1 分钟 STc)计算标准 ST(5 分钟 STo)提供可靠的方程。

结论

更快和更舒适的 ST(1 分钟)是一种可靠的测试,可以使用提供的方程计算睁眼和闭眼时的 5 分钟 ST。1 分钟 STc 不是计算 5 分钟 STo 的可靠测试。

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