Laboratory of Experimental Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Cornea. 2010 May;29(5):497-501. doi: 10.1097/ICO.0b013e3181c2964c.
To compare the 2- and 5-minute Schirmer test I (test without anesthesia) in healthy individuals so as to exploit the possibility of using the 2-minute instead of the 5-minute test.
162 healthy (81 males and 81 females) individuals (without dry eye symptoms and free of pathology affecting tear secretion and tear drainage), aged between 20 and 85 years, were recruited in the study (3 age-groups: 20-45, 46-65, and 66-85 years). Schirmer test I (test without topical anesthesia) was performed in both eyes simultaneously. The values of tear secretion were recorded in 2 and 5 minutes and compared in relation to age and gender. The patients were asked to comment on the duration and the discomfort they felt.
In 2 minutes, the average tear secretion was 12.71 +/- 2.47 mm (mean +/- SD) for the right eyes and 12.62 +/- 2.09 mm for the left eyes and in 5 minutes, 16.74 +/- 3.59 and 16.831 +/- 3.38 mm, respectively. For confidence interval of 99%, the mean values of tear secretion, in individuals who were expected to have normal secretion, were higher than 10 mm in 2 minutes and higher than 13 mm in 5 minutes (significance level 1% or a = 0.01). Only 5.55% of the eyes presented values <10 mm (7-9.5 mm) in the 2-minute test and values <13 mm (8.5-12.5 mm) in the 5-minute test. There was no significant difference in tear secretion between males and females, between the different age-groups, and between right and left eyes. All the examined individuals expressed their negative comments and considered the test as an unpleasant procedure and consequently preferred the shorter possible duration.
The 2-minute test is more acceptable by both the examiners and the examined individuals and may be used, in respect to the above results, as an alternative of the 5-minute test. Normal individuals tend to have Schirmer test I values > or = 10 mm in 2 minutes, irrespective of age and gender.
比较健康个体中 2 分钟和 5 分钟 Schirmer 试验 I（无麻醉），以探索用 2 分钟而非 5 分钟试验的可能性。
共招募了 162 名健康个体（无干眼症状且无影响泪液分泌和泪液排出的病理），年龄在 20 至 85 岁之间（分为 3 个年龄组：20-45 岁、46-65 岁和 66-85 岁）。同时对双眼进行 2 分钟和 5 分钟的 Schirmer 试验 I（无局部麻醉）。记录泪液分泌量，并比较其与年龄和性别之间的关系。患者被要求对持续时间和不适感进行评价。
2 分钟时，右眼和左眼的平均泪液分泌量分别为 12.71±2.47mm 和 12.62±2.09mm；5 分钟时，右眼和左眼的平均泪液分泌量分别为 16.74±3.59mm 和 16.831±3.38mm。在 99%置信区间内，预计有正常分泌的个体，2 分钟时的平均泪液分泌量高于 10mm，5 分钟时高于 13mm（显著水平为 1%或 a=0.01）。只有 5.55%的眼睛在 2 分钟测试中值<10mm（7-9.5mm），在 5 分钟测试中值<13mm（8.5-12.5mm）。男性和女性、不同年龄组以及右眼和左眼之间的泪液分泌量均无显著差异。所有受检者都表示了负面评价，并认为该测试令人不适，因此更喜欢尽可能短的测试时间。
2 分钟测试更受检查者和受检者的认可，可以作为 5 分钟测试的替代。根据上述结果，正常个体的 2 分钟 Schirmer 试验 I 值无论年龄和性别均倾向于≥10mm。
