Glaucoma Research Facility & Clinical Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
J Glaucoma. 2010 Dec;19(9):632-6. doi: 10.1097/IJG.0b013e3181ca7de9.
To study the long-term course of primary angle closure (PAC) eyes after iridotomy.
Seventy-two eyes of 72 patients diagnosed as PAC, having occludable angles with evidence of closure, but no ocular hypertension, were studied. Laser iridotomy was carried out in all eyes at baseline. Standard achromatic perimetry and tonometry were recorded at baseline and serially every 6 months, for at least 4 years. Changes on perimetry and the intraocular pressure (IOP) were analyzed.
At 1 year, 10 eyes and at final review, 26 eyes had developed ocular hypertension and required topical antiglaucoma medication. Eight eyes developed visual field defects on standard achromatic perimetry, over a mean period of 6.89±2.4 years. Eyes that progressed on perimetry, had a significantly narrower angle recess, less than or equal to 10 degrees, P=0.04, and a higher baseline MD and PSD, P=0.004 and 0.03, respectively. They also showed having a larger intervisit IOP fluctuation of 8.9±2.3 mm Hg, cf stable eyes, 6.2±3 mm Hg, P=0.003, and a longer duration of follow-up, P=0.01.
A third of PAC eyes, with very narrow angles, higher global indices, intervisit IOP fluctuations, and a longer duration of follow-up were observed to develop ocular hypertension. A third of the PAC eyes with hypertension, that is 11.1% overall, went on to develop PAC glaucoma.
研究虹膜切开术后原发性闭角型青光眼（PAC）眼的长期病程。
对 72 例诊断为 PAC 的 72 只眼进行研究，这些眼均具有可闭性房角且有粘连证据，但无眼压升高。所有眼均在基线时行激光虹膜切开术。在基线和至少 4 年内每 6 个月进行一次标准全色视野检查和眼压测量。分析视野和眼压的变化。
1 年后 10 只眼和最终随访时 26 只眼发生了眼压升高，需要局部抗青光眼药物治疗。8 只眼在平均 6.89±2.4 年的时间内出现标准全色视野缺损。视野进展的眼，房角隐窝明显变窄，小于或等于 10 度，P=0.04，并且基线 MD 和 PSD 较高，P=0.004 和 0.03。它们还显示出较大的眼压波动，为 8.9±2.3mmHg，而稳定眼为 6.2±3mmHg，P=0.003，随访时间更长，P=0.01。
观察到三分之一的 PAC 眼具有非常狭窄的角度、较高的全局指数、眼压波动较大和随访时间较长，这些眼发生了眼压升高。三分之一的高血压 PAC 眼，即总体的 11.1%，发展为 PAC 青光眼。
