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完全性冠状动脉闭塞:一种不同的情况?

Total coronary occlusion: a different animal?

作者信息

Meier B

机构信息

Cardiology Center, University Hospital, Geneva, Switzerland.

出版信息

J Am Coll Cardiol. 1991 May;17(6 Suppl B):50B-57B. doi: 10.1016/0735-1097(91)90939-7.

DOI:10.1016/0735-1097(91)90939-7
PMID:2016483
Abstract

Provided collateralization is adequate, a chronic total coronary occlusion clinically imitates a 90% stenosis but is exempt from the risk of myocardial infarction. For angioplasty of vessels with chronic total coronary occlusion, technical difficulties and clinical risks are balanced against projected subjective benefit and amount of viable myocardium concerned. The primary success rate is approximately 65% and complications are rare because abrupt vessel reclosure may be common but is harmless. New Q wave infarction in that context has not been reported. The duration of occlusion is the most important predictor of success. The length of the occluded segment is also important. Recurrence averages 68% (21% reocclusion and 47% restenosis) and happens typically within 6 months. The high recurrence rate is due to competitive pressure exerted by collateral vessels and an often suboptimal local result. Even if the primary success rate of angioplasty in vessels with chronic total coronary occlusion can be improved by advanced technology and skill, the clinical yield will remain low compared with that of angioplasty of stenoses. Because low yield procedures must be low risk and low cost, there are definite limits to how sophisticated, risky and expensive new techniques can become. Derivatives of conventional balloon systems are likely to remain the equipment of first choice, perhaps complemented by mechanical drills. Although chronic total coronary occlusions are no clinical menace in contrast to stenoses, they frequently deserve revascularization and are the reason to select bypass surgery over angioplasty. These factors justify endeavors to improve recanalization techniques that help to refine coronary angioplasty of nontotal lesions, because total occlusion, albeit a different animal, is of the same species.

摘要

如果侧支循环充分,慢性冠状动脉完全闭塞在临床上类似于90%的狭窄,但可避免心肌梗死风险。对于慢性冠状动脉完全闭塞血管的血管成形术,技术难度和临床风险需与预期的主观获益及相关存活心肌量相权衡。主要成功率约为65%,并发症罕见,因为血管突然再闭塞虽可能常见但无害。在这种情况下尚未有新的Q波梗死的报道。闭塞持续时间是成功的最重要预测因素。闭塞段长度也很重要。复发率平均为68%(21%再闭塞和47%再狭窄),通常发生在6个月内。高复发率是由于侧支血管施加的竞争压力以及局部结果往往不理想。即使先进技术和技能可提高慢性冠状动脉完全闭塞血管血管成形术的主要成功率,但与狭窄血管成形术相比,临床获益仍将较低。由于低获益的手术必须是低风险和低成本的,新技术能达到多复杂、多有风险和多昂贵是有明确限制的。传统球囊系统的衍生产品可能仍将是首选设备,或许可辅以机械钻。尽管与狭窄相比,慢性冠状动脉完全闭塞并无临床威胁,但它们经常需要血运重建,这也是选择搭桥手术而非血管成形术的原因。这些因素证明努力改进再通技术是合理的,这些技术有助于完善非完全病变的冠状动脉血管成形术,因为完全闭塞虽是不同情况,但仍属于同一类病症。

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Total coronary occlusion: a different animal?完全性冠状动脉闭塞:一种不同的情况?
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引用本文的文献

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Clin Res Cardiol. 2008 Apr;97(4):253-9. doi: 10.1007/s00392-007-0618-5. Epub 2007 Nov 28.
2
Does a well developed collateral circulation predispose to restenosis after percutaneous coronary intervention? An intravascular ultrasound study.发达的侧支循环是否会使经皮冠状动脉介入治疗后再狭窄的倾向增加?一项血管内超声研究。
Heart. 2006 Jun;92(6):763-7. doi: 10.1136/hrt.2005.067322. Epub 2005 Oct 10.
3
Morphology of chronic coronary occlusions and response to interventional therapy--a study by intracoronary ultrasound.
慢性冠状动脉闭塞的形态学及对介入治疗的反应——一项冠状动脉内超声研究
Int J Card Imaging. 1997 Dec;13(6):475-84. doi: 10.1023/a:1005847404993.