Harrison D G
Department of Medicine, Emory University, Atlanta, Georgia 30322.
J Am Coll Cardiol. 1991 May;17(6 Suppl B):71B-76B. doi: 10.1016/0735-1097(91)90941-2.
The vascular endothelium importantly modulates many biochemical and physiologic properties of the vascular wall, including the release of potent vasoactive factors, maintenance of an anticoagulant state and modulation of vascular growth by the release of both proliferative and antiproliferative substances. Prominent among these endothelial roles is the production of a potent vasodilator or family of vasodilators termed the endothelium-derived relaxing factor, one of which has been identified to be nitric oxide or a closely related compound. Several diseases that commonly occur in patients undergoing coronary angioplasty alter many facets of endothelial function and may predispose to adverse clinical sequelae of angioplasty, including immediate thrombosis, restenosis and vascular spasm. Several features of the endothelium-derived relaxing factor, how it is altered by pathologic processes and how these considerations relate to the immediate and late postangioplasty periods are discussed.
血管内皮对血管壁的许多生化和生理特性起着重要的调节作用，包括释放强效血管活性因子、维持抗凝状态以及通过释放增殖性和抗增殖性物质来调节血管生长。这些内皮功能中突出的一点是产生一种强效血管舒张剂或一类血管舒张剂，称为内皮源性舒张因子，其中一种已被确定为一氧化氮或与之密切相关的化合物。接受冠状动脉血管成形术的患者中常见的几种疾病会改变内皮功能的许多方面，并可能导致血管成形术的不良临床后果，包括即刻血栓形成、再狭窄和血管痉挛。本文将讨论内皮源性舒张因子的几个特点、它如何被病理过程改变以及这些因素与血管成形术后即刻和晚期的关系。
