结核性胸腔积液中的腺苷脱氨酶（ADA）水平
Adenosine Deaminase (ADA) Level in Tubercular Pleural Effusion.
作者信息
Verma S K, Dubey A L, Singh P A, Tewerson S L, Sharma Davashish
机构信息
Department of TB & Chest Diseases, CSM Medical University, Lucknow, India.
出版信息
Lung India. 2008 Jul;25(3):109-10. doi: 10.4103/0970-2113.44121.
STUDY OBJECTIVE
To study the value of adenosine deaminase level in tuber-cular pleural effusion.
DESIGN
A hospital based observational study.
SETTING
Out and In patients service of department of Tuberculosis & Chest Diseases, MLN Medical College Allahabad.
PATIENTS
50 consecutive patients of pleural effusion, who were above the age of 12 years, were studied.
RESULTS
Pleural fluid adenosine deaminase was more than 36 IU/L (36 to 229.7 IU/L) in tubercular pleural effusion (34 patients). In case of malignancy no. of patients was 08 and pleural fluid adenosine deaminase was more than 18.5 IU/L (18.5 to 87.6 IU/L). While in one case of hypoprotenemiea pleural fluid adenosine deaminase was 8.21 IU/L. If 36 IU/L is taken as cut of limit the sensitiv-ity and specificity of ADA for tuberculosis is 100 % and 77.7 %. More than 100 IU/L was exclusively seen in tubercular pleural effusion.
CONCLUSION
ADA > 100IU/L was observed in TB only.
研究目的
探讨腺苷脱氨酶水平在结核性胸腔积液中的价值。
设计
一项基于医院的观察性研究。
地点
阿拉哈巴德MLN医学院结核病与胸部疾病科的门诊及住院患者服务部。
患者
研究了50例年龄在12岁以上的连续性胸腔积液患者。
结果
结核性胸腔积液（34例患者）中胸腔积液腺苷脱氨酶超过36 IU/L（36至229.7 IU/L）。恶性肿瘤患者有8例，胸腔积液腺苷脱氨酶超过18.5 IU/L（18.5至87.6 IU/L）。而在1例低蛋白血症患者中，胸腔积液腺苷脱氨酶为8.21 IU/L。若以36 IU/L作为临界值，腺苷脱氨酶对结核病的敏感性和特异性分别为100%和77.7%。超过100 IU/L仅见于结核性胸腔积液。
结论
仅在结核病中观察到ADA>100IU/L。
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