脯氨酸锂盐介导的多组分不对称反应。
Multicomponent asymmetric reactions mediated by proline lithium salt.
机构信息
Dipartimento di Chimica, Università Sapienza di Roma, and Istituto di Chimica Biomolecolare del CNR, P.le Aldo Moro 5, 00185, Roma, Italy.
出版信息
Org Biomol Chem. 2010 Mar 7;8(5):980-3. doi: 10.1039/b924158b. Epub 2010 Jan 13.
DOI:10.1039/b924158b
PMID:20165783
Abstract
The multicomponent reaction between proline lithium salt, 2-cyclohexen-1-one and aliphatic aldehydes affords the 4-alkylidene-2-cyclohexen-1-ones, which are interesting fragrances, and bicyclic amino acids that bear four additional stereocenters, obtained as single stereoisomer.
摘要
脯氨酸锂盐、2-环己烯-1-酮与脂肪醛的多组分反应生成了 4-亚烷基-2-环己烯-1-酮，这些是有趣的香料，以及双环氨基酸，它们带有四个额外的立体中心，且作为单一立体异构体获得。
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