详细研究氮杂-Prins 反应。
A detailed investigation of the aza-Prins reaction.
机构信息
School of Biological and Chemical Sciences, Joseph Priestley Building, Queen Mary University of London, Mile End Road, London, United Kingdom E1 4NS.
出版信息
Org Biomol Chem. 2010 Mar 7;8(5):1064-80. doi: 10.1039/b915797b. Epub 2010 Jan 5.
DOI:10.1039/b915797b
PMID:20165797
Abstract
The development of a Lewis acid-promoted aza-Prins reaction to form piperidines and pyrrolidines is described. Indium trichloride has been found to be a highly successful and mild Lewis acid for promoting this reaction. A thorough mechanistic investigation is described, including the factors that influence the formation of the 5- or 6-membered ring product(s).
摘要
描述了一种路易斯酸促进的氮杂-Prins 反应来形成哌啶和吡咯烷。三氯化铟被发现是一种非常成功和温和的路易斯酸，可以促进这种反应。描述了一项彻底的机理研究，包括影响 5-或 6-元环产物形成的因素。
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