Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway.
Strahlenther Onkol. 2010 Mar;186(3):163-8. doi: 10.1007/s00066-010-2040-6. Epub 2010 Feb 22.
To investigate the lung tissue response measured with computed tomography (CT) after radiotherapy (RT) combined with metoclopramide.
Patients with non-small cell lung cancer (tumor stage IIIA and IIIB), included in a multicenter, randomized phase III trial investigating the use of metoclopramide as a radiosensitizing agent, were examined with repetitive post-RT CT scans. The analysis comprised data up to 100 days after RT for a subgroup of 16 patients treated with a total dose of 60 Gy given in 1.82 Gy per fraction.
Large radiation doses to subvolumes were associated with denser lung tissue measured with CT (p < 0.001). Opposed to this finding, the volume of lung tissue irradiated with significant doses (V(40Gy)) was negatively correlated with the average increase in lung tissue density (p = 0.003). Patients randomized to metoclopramide injections also experienced less increase in lung tissue density (p = 0.01).
There was an increase in the density of irradiated lung tissue with radiation dose and time after RT. Metoclopramide and significant radiation doses to larger lung volumes (V(40Gy)) seemed to protect against fibrosis development.
研究放疗（RT）联合甲氧氯普胺后通过计算机断层扫描（CT）测量的肺组织反应。
本研究纳入了参加多中心、随机 III 期试验的非小细胞肺癌（肿瘤分期 IIIA 和 IIIB）患者，旨在研究甲氧氯普胺作为放射增敏剂的作用。对这些患者进行重复的 RT 后 CT 扫描。对于 16 名接受 60Gy 总剂量（1.82Gy/次）治疗的亚组患者，分析了 RT 后 100 天内的数据。
CT 测量的亚体积大剂量照射与更致密的肺组织相关（p<0.001）。与此发现相反，用显著剂量（V（40Gy））照射的肺组织体积与肺组织密度的平均增加呈负相关（p=0.003）。接受甲氧氯普胺注射的患者肺组织密度增加也较少（p=0.01）。
RT 后随着剂量和时间的增加，照射的肺组织密度增加。甲氧氯普胺和较大肺体积（V（40Gy））的大剂量照射似乎可以预防纤维化的发生。
