National Institute for Infectious Diseases IRCCS Lazzaro Spallanzani, 00149, Rome, Italy.
Cell Mol Life Sci. 2010 May;67(10):1581-8. doi: 10.1007/s00018-010-0284-z. Epub 2010 Feb 18.
A growing number of publications show that apoptosis induction is often associated with increased autophagy indicating the existence of an interplay between these two important cellular events. The simultaneous activation of both phenomena has been detected not only in experimental settings but also in vivo under physiological and pathological conditions. Despite these studies, the reciprocal influence of the two pathways in vivo has still not been completely understood. It is clear that autophagy and apoptosis are strictly interconnected, as highlighted by the finding that the two pathways share key molecular regulators. Many novel aspects of the crosstalk between apoptosis and autophagy have recently emerged showing how complex is this relationship and how critical is for the overall fate of the cell. In this mini-review we will focus on some key experiments trying to decipher as to whether autophagy contributes to apoptosis modulation in vivo.
越来越多的出版物表明，细胞凋亡的诱导通常与自噬的增加有关，这表明这两种重要的细胞事件之间存在相互作用。这两种现象的同时激活不仅在实验环境中被检测到，而且在生理和病理条件下也在体内被检测到。尽管进行了这些研究，但这两条途径在体内的相互影响仍未完全理解。很明显，自噬和细胞凋亡是严格相互关联的，这一点从两条途径共享关键分子调节剂的发现中得到了强调。最近出现了细胞凋亡和自噬之间相互作用的许多新方面，表明这种关系是多么复杂，以及对细胞的整体命运是多么关键。在这篇迷你综述中，我们将重点介绍一些试图阐明自噬是否有助于体内细胞凋亡调节的关键实验。
