Li Yuan-Hong, Wu Yan, Chen John Z S, Zhu Xia, Xu Yuan-Yuan, Chen Jing, Dong Guang-Hui, Gao Xing-Hua, Chen Hong-Duo
Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, PR China.
Lasers Surg Med. 2010 Feb;42(2):185-91. doi: 10.1002/lsm.20889.
Intense pulsed light (IPL) is regarded as the gold standard of nonablative photo-rejuvenation. Yet there is still a need to observe its efficacy and safety on dark skin using a split-face module.
STUDY DESIGN/MATERIALS AND METHODS: Twenty-four Chinese women with photoaging were enrolled in this study. Patients were randomized to receive four IPL treatments at 3- to 4-week intervals on one side of face, with the other side spared as control. Changes of photoaging were evaluated using a global evaluation, an overall self-assessment, a Mexameter and a Corneometer. Skin biopsies were taken after four sessions of treatment on one side of face. The melanocyte density and the contents of melanin, collagen fibers, and elastic fibers were stained and used to evaluate the improvement on dyschromia and other signs of photoaging.
The global scores of photoaging on treated side decreased significantly from 3.02 to 1.22, while it remained unchanged on the untreated side. Twenty-one of 24 patients (87.5%) rated their improvement as excellent or good. The difference on the values of melanin index and erythema index on treated side were significantly larger than those on untreated side after the 1st session, the 4th session and at 3-month follow-up (P<0.05). The melanin contents were significantly decreased and the collagen fibers were obviously increased only on treated side (P<0.05). Adverse effects of treated side were limited to mild pain and transient erythema.
Using this split-face module, IPL treatment is proved both clinically and histologically to be effective in treating photoaging skin in Chinese population. Adverse effects were minimal and acceptable.
强脉冲光（IPL）被视为非剥脱性光嫩肤的金标准。然而，仍有必要采用双侧面部对照模式观察其对深色皮肤的疗效和安全性。
研究设计/材料与方法：本研究纳入了24名有光老化问题的中国女性。患者被随机分为两组，一组在面部一侧每隔3至4周接受4次IPL治疗，另一侧作为对照不进行治疗。采用整体评估、总体自我评估、黑色素仪和角质层水合测定仪评估光老化的变化。在面部一侧进行4次治疗后取皮肤活检。对黑素细胞密度以及黑色素、胶原纤维和弹性纤维的含量进行染色，以评估色素沉着异常和其他光老化迹象的改善情况。
治疗侧光老化的整体评分从3.02显著降至1.22，而未治疗侧保持不变。24名患者中有21名（87.5%）将其改善情况评为优秀或良好。在第1次治疗后、第4次治疗后以及3个月随访时，治疗侧的黑色素指数和红斑指数值与未治疗侧相比差异显著（P<0.05）。仅治疗侧的黑色素含量显著降低，胶原纤维明显增加（P<0.05）。治疗侧的不良反应仅限于轻度疼痛和短暂红斑。
采用这种双侧面部对照模式，IPL治疗在中国人群光老化皮肤的治疗中经临床和组织学证明是有效的。不良反应轻微且可接受。
