Jiang Min, Yan Fang, Avram Mathew, Lu Zhong
Department of Dermatology, Huashan Hospital, Fudan University, No. 12 Wulumuqi Zhong Road, Shanghain, 200040, China.
MGH Dermatology Laser and Cosmetic Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, MA, 02114, USA.
Lasers Med Sci. 2017 Jul;32(5):1051-1061. doi: 10.1007/s10103-017-2207-9. Epub 2017 Apr 23.
The clinical features of photoaging include: skin texture changes, laxity, rhytides, pigmentary changes, and vascular changes such as erythema and telangiectasias. In order to meet patients' increasing demands for improving all aspects of photoaging at one office visit, employing a multi-modality treatment for all aspects of photoaging has become increasingly desirable for the physician and patient alike. We examine a novel device that employs bipolar radiofrequency (RF), intense pulsed light (IPL), and infrared diode laser. These laser and light source treatments are performed sequentially. This study aims to evaluate the clinical efficacy and safety of this device (i.e., ELOS Triniti™). Twenty-six subjects received four ELOS Triniti™ treatments at 1-month intervals. They were followed up 1, 3, and 6 months after completing the treatments. Two blinded dermatologists used a comprehensive grading scale to evaluate the degree of the photoaging in terms of rhytides, laxity, dyschromia, erythema, telangiectasias, and texture. Subjects used a 0-10 grading scale for self-assessment of photoaging. Additionally, we measured the Erythema Index (EI), Melanin Index (MI), transepidermal water loss scores (TEWL), stratum corneum moisture scores (SC), and dermis moisture scores (D) before treatment and 1, 3, and 6 months after treatment. There was a statistically significant improvement in all five aspects of the comprehensive grading scale. Overall, it had excellent efficacy for improving erythema, telangiectasias, and skin texture. It also had a relatively long effect on improving skin laxity; however, it had only a limited ability to improve rhytides and dyschromia. It can mildly to moderately improve the global photoaging. This global effect can be noted 1 month after treatment and becomes most clinically apparent 3 months after treatment. This is maintained at least 6 months after treatment. MI index and SC and D values increased while EI index and TEWL values decreased after the treatment. The subjects' self-assessment improved by 2.7 ± 1.2 points. The overall satisfaction rate was 88%. The degree of pain measured 2.5 ± 1.9 points on average. There was no downtime and no severe side effects reported. The sequential implementation of bipolar radiofrequency based optical combination devices (IPL, IR, diode laser) is effective and safe for global facial photoaging.
皮肤质地改变、松弛、皱纹、色素沉着变化以及血管变化,如红斑和毛细血管扩张。为了满足患者在一次就诊中改善光老化各个方面的日益增长的需求,对光老化的各个方面采用多模式治疗对医生和患者来说都变得越来越可取。我们研究了一种采用双极射频(RF)、强脉冲光(IPL)和红外二极管激光的新型设备。这些激光和光源治疗是依次进行的。本研究旨在评估该设备(即ELOS Triniti™)的临床疗效和安全性。26名受试者每隔1个月接受4次ELOS Triniti™治疗。在完成治疗后1、3和6个月对他们进行随访。两名盲法皮肤科医生使用综合评分量表,从皱纹、松弛、色素异常、红斑、毛细血管扩张和质地方面评估光老化程度。受试者使用0至10分的评分量表对光老化进行自我评估。此外,我们在治疗前以及治疗后1、3和6个月测量了红斑指数(EI)、黑色素指数(MI)、经表皮水分流失分数(TEWL)、角质层水分分数(SC)和真皮水分分数(D)。综合评分量表的所有五个方面均有统计学上的显著改善。总体而言,它在改善红斑、毛细血管扩张和皮肤质地方面具有出色的疗效。在改善皮肤松弛方面也有相对持久的效果;然而,它在改善皱纹和色素异常方面的能力有限。它可以轻度至中度改善整体光老化。这种整体效果在治疗后1个月即可观察到,在治疗后3个月在临床上最为明显。这种效果在治疗后至少维持6个月。治疗后MI指数以及SC和D值升高,而EI指数和TEWL值降低。受试者的自我评估提高了2.7±1.2分。总体满意率为88%。平均疼痛程度为2.5±1.9分。未报告有停工时间和严重副作用。基于双极射频的光学组合设备(IPL、IR、二极管激光)依次实施对全面部光老化有效且安全。