CAS Key Laboratory of Engineering Plastics, Joint Laboratory of Polymer Sciences and Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Macromol Biosci. 2010 Jun 11;10(6):621-31. doi: 10.1002/mabi.200900434.
Thermosensitive nanoparticles with a core-shell structure were prepared by self-assembly of PCL-b-PEO-b-PNIPAAm triblock copolymers, which were synthesized by anionic ring-opening polymerization and reversible addition fragmentation chain transfer (RAFT) polymerization. At temperatures above the lower critical solution temperature (LCST), the collapse of PNIPAAm chains in the outer shell and in the core of nanoparticle caused a decrease in size, while the constantly hydrophilic PEO chains in the shell endowed nanoparticles with excellent stability in water. The release of doxorubicin from these nanoparticles showed that both the length of PNIPAAm chains and temperature have great influence on drug release, which indicates the great potential of thermosensitive nanoparticles as drug carriers.
采用阴离子开环聚合和可逆加成-断裂链转移（RAFT）聚合制备了具有核壳结构的 PCL-b-PEO-b-PNIPAAm 嵌段共聚物，通过自组装制备了温敏纳米粒子。在高于下临界溶液温度（LCST）的温度下，纳米粒子外壳和内核中 PNIPAAm 链的塌陷导致粒径减小，而壳中不断亲水的 PEO 链赋予纳米粒子在水中优异的稳定性。阿霉素从这些纳米粒子中的释放表明 PNIPAAm 链的长度和温度对药物释放有很大的影响，这表明温敏纳米粒子作为药物载体具有很大的潜力。
