Karakitsos Dimitrios, Karabinis Andreas, Kotsiou Antonia
Department of Intensive Care Unit, General State Hospital of Athens, Athens, Hellas.
Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):143-6. doi: 10.1007/BF03191164.
Hyperlipidaemic diets induce increase in serum lipid profile (total cholesterol, triglycerides, LDL etc). It has also been proven that stress interferes in lipid metabolism. Many drugs modify their pharmacokinetic properties in presence of lipoproteins, as a result of alterations in their plasma protein and tissue binding. Lidocaine, a synthetic amide, used as a local anesthetic and secondary as antiarrhythmic agent is also protein bound and therefore conditions, which favor lidocaine dissociation from plasma proteins, modify its pharmacokinetic profile. The purpose of this study was: To investigate and compare the effects of stress( cold water 4 degrees C swimming of 20 days duration) and various high lipid diets (olive oil, butter, sunflower oil) on the serum and tissue (liver and tongue) levels of 14C lidocaine.
高脂血症饮食会导致血清脂质谱（总胆固醇、甘油三酯、低密度脂蛋白等）升高。研究还证实，应激会干扰脂质代谢。许多药物在脂蛋白存在的情况下会改变其药代动力学特性，这是由于其血浆蛋白和组织结合发生了改变。利多卡因是一种合成酰胺，用作局部麻醉剂，其次用作抗心律失常药物，它也与蛋白质结合，因此，有利于利多卡因从血浆蛋白中解离的条件会改变其药代动力学特征。本研究的目的是：研究并比较应激（持续20天的4℃冷水游泳）和各种高脂饮食（橄榄油、黄油、葵花籽油）对14C利多卡因血清和组织（肝脏和舌头）水平的影响。
